Having played NLHE and LHE for some time, I am very aware of all the aspects that go into "playing the game".
I am fairly good at the NLHE as my online and casino stacks often show, recently (as seen in another question) I've been playing with a few new players from work and classes and they are very new to the game. Now they are smart people, so rules questions aren't so prevalent, but I find that my usual reads and hand estimations are wildly inaccurate. One hand I'll expect him to have a high board pair / high pocket pair and he'll have nothing. Another I'll see him bet big on the turn with all clubs showing, and I'll fold out only to see that he had a mediocre pair. Later in the night I lost a big pot because I expected a pair or maybe trips and he drops a full house on me for a big loss.
I've resorted to playing strict percentages (as if I'm playing online) and removing most of the items that I usually take into account (player position, bet size in relation to pot/own stack/my stack, past hand betting) and only playing my cards.
What strategies do other veteran players take when dealing with the sometimes chaotic playing patterns of novice or rookie players?