Statistically any down card is an unknown card. In a hole card or muck is a down card.
Certain cards are played more than others. For example Ace is the most played cards. Yes there are some ace rag hands you don't play with an Ace but there are are a lot you do. 2-7 you pretty never play or only play as a pair.
Not everyone plays top 10% and it will vary by position but consider that case. Not everyone has the same top 10% but this is one. You also need to consider how many ways to make the hand. There are 6 ways to make a pair, 4 ways to make suited, and 16 ways to make unsuited not paired.
combinations
A A 6
K K 6
Q Q 6
J J 6
T T 6
9 9 6
8 8 6
7 7 6
A K s 4
A Q s 4
A J s 4
A T s 4
A 9 s 4
K Q s 4
K J s 4
K T s 4
Q T s 4
A K 16
A Q 16
A J 16
K Q 16
If you add those up what is the percentage of each of those cards
card count
A 148 50.0%
K 68 23.0%
Q 20 6.8%
J 12 4.1%
T 12 4.1%
9 12 4.1%
8 12 4.1%
7 12 4.1%
Pretty interesting that if someone is playing 10% and they play the hand based on that alone then 50% of the time they are holding one or two aces.
Card removal is real but it does does NOT really matter
Card removal has the same effect on every player. AK going from slight dog to a slight favorite does not change the way the game should be played. You should open from mid to late with AK not because you have a better chance of pairing the board - play it because open in mid to late position it is likely the best hand. Don't open 46o because it has a worse chance of pairing the board behind multiple folds - fold it because it is a bad hand. Card removal does not change the relative strength of hands enough to be a factor. People new to poker math seem to fixate on this and my advice is acknowledge and then immediately ignore.
Take JJ as the sample case. It is a very good hand with very few card removal blockers. Behind a raise and re-raise it is likely beat. Because you are beat actually improves the chance of spiking spiking a third J on the flop by maybe a whole 1%. Does not make JJ any more playable in that spot.
If you play 87s multi-way then yes your chance of pairing goes up base on card removal. And if you hit top pair on the flop your chance of being top pair goes up as K8- and a lot of other combos don't play. Newsflash 99+ is playing the hand and still has you beat. Card removal is real but does not really even rise to statistical noise.