Someone who never took insurance would do better in the long run than somebody who took insurance. 

Ultimately it's a subjective question since you are losing EV. Only you can answer if the juice is worth it to you to reduce variance. It's easy to construct hypothetical situations in which I would take insurance in real life, given a large enough pot. That being said I have never taken it or wanted to take it at the table.

Clearly there are cases in real life where taking insurance is rational, typically to insure against losses that are too difficult to replace. You shouldn't run into those cases playing poker. IMO wanting to take insurance is a sign that you're playing above your bankroll.